Stop searching for
the needle in the haystack

Accelerate your lead discovery by design smart  libraries
with sophisticated randomization scheme
that allow to test your boldest hypothesis.

Precision Libraries

Saturated libraries

NNK libraries

Scanning Libraries

Explore more of what you need and none of what you don't

The perfect one

Officinae Bio's precision variant libraries allow researchers to achieve unparalleled control over each synthesized variant. The result is the creation of a diverse and fully represented mutant library with controlled distribution of amino acids. 

This precision streamlines discovery workflows and ensures that your desired variation of the library is captured without the need for exhaustive, repetitive screening.

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Precision libraries Pro

Our flagship product, Precision libraries Pro enable you to design variants encoding a different subset of AA at each position using your custom-defined AA ratio.

E.g.: G125 to 60% A, 20% V, 10% L and 10% S

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Precision libraries

Go beyond NNK, Precision libraries enable you to design variants encoding a different subset of AA at each position using a balanced codon usage.

E.g.: G125 to 25% A, 25% V, 25% L and 25%S

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Site Saturation Variant Libraries

Test what evolution didn’t dare to!

Saturation libraries enable you to test all non-wild type amino acids using our state of the art balanced codon usage. Site Saturation Libraries eliminate codon bias and unwanted substitutions unlike traditional methods such as degenerate and NNK approaches to deliver highly uniform variant libraries containing all non-wild type amino acids (and no STOP codons)

E.g.: G125 to 0.053% non-wild type AA, no STOP codons

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Fully randomized NNK libraries

Quickly assess the sequence space with our convenient NNK fully randomized libraries that encodes all amino acids while having only one STOP codons (TAG) that can be translated as Gly in E.coli Amber mutants. 

E.g.: G125 to all AA and 1 STOP codon.

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Scanning libraries

Quickly and conveniently assess the role of individual amino acids with our Scanning libraries by mutating a consecutive string of amino acids within a defined region to a specific codon.
For example, in alanine scanning, each amino acid in a selected segment is systematically substituted with alanine. This approach helps researchers identify which residues are essential for protein function by observing the effects of these substitutions on the protein’s activity, stability, or interactions.

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Quality Control

QC perfect for your downstream application

Ensuring pristine DNA quality is paramount in the pursuit of reliable and reproducible results, and our stringent quality control standards guarantee excellence at every step. Employing industry-leading benchmarks, we meticulously assess DNA integrity and purity to meet the highest scientific standards.

Sample purity and integrity by UV spectroscopy and capillary electrophoresis

Sequence identity by Sanger sequencing and NGS

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Move confidently from designing to testing with our rigorous quality control standards

Discuss your next project with one of our experts

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