Your mRNA,

engineered for success.

We accelerate your discovery-to-preclinical timelines by leveraging proprietary machine learning to optimize RNA sequence design and mRNA manufacturing.

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Increase protein expression.

Achieve superior mRNA performance with Mercurius, Officinae Bio’s AI-powered design engine. By modelling complex biological dependencies, Mercurius optimizes 5' and 3' UTRs, polyA tails, and regulatory elements for application-specific, tissue-aware expression.

In cell-based assays, OB-engineered mRNAs show significantly higher protein expression than commercial benchmarks.

From protein replacement to gene editing and cancer immunotherapy, Mercurius consistently delivers best-in-class expression.

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Enhance tissue specificity

Achieve targeted expression where it matters most. Officinae Bio’s AI-powered design pipeline, Mercurius, leverages a proprietary computational pipeline to optimize UTRs and polyA tails, enhancing mRNA translation in target tissues while minimizing off-target expression.

In vivo studies in BALB/c mice demonstrate that OB-engineered mRNAs achieve higher lung-to-spleen expression ratios compared to commercial benchmarks.

From lung-targeted delivery to immune cell applications, Mercurius may enable precise and effective tissue-specific mRNA expression tailored to your therapeutic goals.

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Your mRNA, engineered for success

Achieve a superior Effective Therapeutic Index

Accelerate the transition from discovery to preclinical stages by optimizing the Effective Therapeutic Index through fine-tuning of in vivo expression (efficacy)  and  the enhancement of tissue specificity (safety).

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Mercurius

Our AI-powered workflow for mRNA design

Our Mercurius AI platform integrates public and proprietary data into a knowledge graph, enriched by Bayesian networks that capture complex dependencies and uncertainties across biological variables. This structure enables context-aware reasoning to inform both sequence design and process parameters.

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Mercurius leverages this enriched data landscape to compute the conditional probabilities of different sequence designs—optimizing UTRs, polyA tails, capping strategies, and chemical modifications—to meet your specific expression, safety, and targeting goals.

Our Service Bundles

Phase-appropriate, Application-Specific

Accelerate your development with Officinae Bio’s phase appropriate and application specific service bundles, spanning discovery to preclinical and addressing needs from protein replacement to cancer immunotherapeutics.

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Our Service Bundles at a Glance

HITSmart
LEADvantage
BIOptima
You provide
Gene of Interest and Cell line of choice
Gene of Interest and target organ
DNA template and process requirment
What we do
Cell line-tailored codon and UTR optimization of your GOI to boost expression and targeted activity.
Organ-specific optimization of codon, UTR, cap, and modifications to enhance expression, safety, and targeting.
IVT optimization and validation through adaptive Design of Experiments.
We deliver
6 custom mRNAs + 1 control GFP mRNA
3 custom mRNAs + 1 control Luc mRNA
3 optimize processes and corresponding mRNAs for testing
Custom DNA synthesis
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Custom Gene IVT
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Quantity
5 ug/each
150 ug/each
500 ug/each
Purity
Transfection-ready
Pre-clinical grade
R&D Grade
Turn-around time
21 Business days
31 business days
45 business days
Price
from 5,000 eur
from 15,000 eur
from 15,000 eur
From Idea to Commercial Scale

Accelerate Your mRNA Journey with Confidence

As part of the Maravai LifeSciences ecosystem, Officinae Bio gives you seamless access to comprehensive mRNA solutions, from design and development to GMP manufacturing and commercial production, leveraging clinically approved critical reagents.

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TriLink Biotechnologies

Clinically approved mRNA reagents with CleanCap® technology.

TriLink Biotechnologies
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Cygnus Technologies

Gold-standard for impurity detection, from preclinical development to commercial release.

Cygnus Technologies
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Alphazyme

Trusted source of ISO 13485:2016-certified high-performance enzymes for mRNA manufacturing.

Alphazyme
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Glen Research

The leading provider of reagents for DNA and RNA oligonucleotide synthesis and purification.

Glen Research

From our Blog

Nuanced Engineering: Rethinking Codon Optimization in mRNA Medicine
mRNA

Nuanced Engineering: Rethinking Codon Optimization in mRNA Medicine

Jun 15, 2025 9:23:37 AM 4 min read
From Generic to Smart: It’s Time to Rethink mRNA UTRs
mRNA

From Generic to Smart: It’s Time to Rethink mRNA UTRs

Jun 13, 2025 9:30:08 AM 2 min read
Beyond Peak Expression: Rethinking Control in mRNA Therapeutics
mRNA

Beyond Peak Expression: Rethinking Control in mRNA Therapeutics

Jun 11, 2025 5:11:18 PM 2 min read

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